UCSF

Purpose

To learn bone shape features from spherical bone map of knee MRI images using established convolutional neural networks (CNN) and use these features to diagnose and predict osteoarthritis (OA).

Methods

A bone segmentation model was trained on 25 manually annotated 3D MRI volumes to segment the femur, tibia, and patella from 47 078 3D MRI volumes. Each bone segmentation was converted to a 3D point cloud and transformed into spherical coordinates. Different fusion strategies were performed to merge spherical maps obtained by each bone. A total of 41 822 merged spherical maps with corresponding Kellgren-Lawrence grades for radiographic OA were used to train a CNN classifier model to diagnose OA using bone shape learned features. Several OA Diagnosis models were tested and the weights for each trained model were transferred to the OA Incidence models. The OA incidence task consisted of predicting OA from a healthy scan within a range of eight time points, from 1 y to 8 y. The validation performance was compared and the test set performance was reported.

Results

The OA Diagnosis model had an area-under-the-curve (AUC) of 0.905 on the test set with a sensitivity and specificity of 0.815 and 0.839. The OA Incidence models had an AUC ranging from 0.841 to 0.646 on the test set for the range from 1 y to 8 y.

Conclusion

Bone shape was successfully used as a predictive imaging biomarker for OA. This approach is novel in the field of deep learning applications for musculoskeletal imaging and can be expanded to other OA biomarkers.