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The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation
Published Web Location
https://doi.org/10.2217/epi-2018-0042Abstract
Aim
To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.Materials & methods
In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined.Results
Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions.Conclusion
Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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