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Sperm Motility Requires Wnt/GSK3 Stabilization of Proteins
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https://doi.org/10.1016/j.devcel.2015.11.009Abstract
Inhibition of GSK3 by Wnt signaling stabilizes many cellular proteins, but proof that this effect is independent of β-catenin-mediated transcription is lacking. Koch, Acebron, and colleagues (2015) now demonstrate that transcriptionally silent mammalian sperm require Wnt signaling via exosomes to prevent protein degradation during their lengthy travels through the epididymis.
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