Bronsted Acid-Catalyzed Intramolecular Hydroarylation of beta-Benzylstyrenes
- Author(s): Cai, X
- Keshavarz, A
- Omaque, JD
- Stokes, BJ
- et al.
Published Web Locationhttps://doi.org/10.1021/acs.orglett.7b00958
Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Brønsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.
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