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Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR.

  • Author(s): Dehn, Jason
  • Spellman, Stephen
  • Hurley, Carolyn K
  • Shaw, Bronwen E
  • Barker, Juliet N
  • Burns, Linda J
  • Confer, Dennis L
  • Eapen, Mary
  • Fernandez-Vina, Marcelo
  • Hartzman, Robert
  • Maiers, Martin
  • Marino, Susana R
  • Mueller, Carlheinz
  • Perales, Miguel-Angel
  • Rajalingam, Raja
  • Pidala, Joseph
  • et al.
Abstract

Allogeneic hematopoietic cell transplantation involves consideration of both donor and recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution donor-recipient HLA match is of primary importance in transplantation with adult unrelated donors, using conventional graft-versus-host disease prophylaxis. In cord blood transplantation, optimal unit selection requires consideration of unit quality, cell dose and HLA-match. In this summary, the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research, jointly with the NMDP Histocompatibility Advisory Group, provide evidence-based guidelines for optimal selection of unrelated donors and cord blood units.

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