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Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency

  • Author(s): Dvorak, CC
  • Hassan, A
  • Slatter, MA
  • Hönig, M
  • Lankester, AC
  • Buckley, RH
  • Pulsipher, MA
  • Davis, JH
  • Güngör, T
  • Gabriel, M
  • Bleesing, JH
  • Bunin, N
  • Sedlacek, P
  • Connelly, JA
  • Crawford, DF
  • Notarangelo, LD
  • Pai, SY
  • Hassid, J
  • Veys, P
  • Gennery, AR
  • Cowan, MJ
  • et al.

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Background Patients with severe combined immunodeficiency disease who have matched sibling donors (MSDs) can proceed to hematopoietic cell transplantation (HCT) without conditioning chemotherapy. Objective We sought to determine whether the results of HCT without chemotherapy-based conditioning from matched unrelated donors (URDs), either from volunteer adults or umbilical cord blood, are comparable with those from MSDs.

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