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D2 antagonist during development decreases anxiety and infanticidal behavior in adult female prairie voles (Microtus ochrogaster)
Published Web Location
http://www.ncbi.nlm.nih.gov/pubmed/?term=D2+antagonist+during+development+decreases+anxiety+and+infanticidal+behavior+in+adult+female+prairie+voles+(Microtus+ochrogaster)No data is associated with this publication.
Abstract
On postnatal day 8, prairie vole pups were randomly assigned a treatment of 1mg/kg SKF38393 (D1 agonist), quinpirole (D2 agonist), SCH23390 (D1 antagonist), eticlopride (D2 antagonist), or saline vehicle. As adults, females treated with eticlopride exhibited reduced anxiety-like behavior in an elevated plus maze and a reduction in infanticidal behavior. These behavioral effects were not seen in males. These data demonstrate that a single exposure to a D2 antagonist during development can have persistent, sex-specific effects on behavior into adulthood.
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