Sprouty genes regulate proliferation and survival of human embryonic stem cells
- Author(s): Klein, Ophir;
- Felfly, H;
- Klein, OD
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3721083?pdf=render
Sprouty (Spry) genes encode negative regulators of receptor tyrosine kinase (RTK) signaling, which plays important roles in human embryonic stem cells (hESCs). SPRY2 and SPRY4 are the two most highly expressed Sprouty family members in hESCs, suggesting th