Skip to main content
Download PDF
- Main
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
- de Silva, Thushan I;
- Liu, Guihai;
- Lindsey, Benjamin B;
- Dong, Danning;
- Moore, Shona C;
- Hsu, Nienyun Sharon;
- Shah, Dhruv;
- Wellington, Dannielle;
- Mentzer, Alexander J;
- Angyal, Adrienn;
- Brown, Rebecca;
- Parker, Matthew D;
- Ying, Zixi;
- Yao, Xuan;
- Turtle, Lance;
- Dunachie, Susanna;
- Aanensen, David M;
- Abudahab, Khalil;
- Adams, Helen;
- Adams, Alexander;
- Afifi, Safiah;
- Aggarwal, Dinesh;
- Ahmad, Shazaad SY;
- Aigrain, Louise;
- Alcolea-Medina, Adela;
- Alikhan, Nabil-Fareed;
- Allara, Elias;
- Amato, Roberto;
- Annett, Tara;
- Aplin, Stephen;
- Ariani, Cristina V;
- Asad, Hibo;
- Ash, Amy;
- Ashfield, Paula;
- Ashford, Fiona;
- Atkinson, Laura;
- Attwood, Stephen W;
- Auckland, Cressida;
- Aydin, Alp;
- Baker, David J;
- Baker, Paul;
- Balcazar, Carlos E;
- Ball, Jonathan;
- Barrett, Jeffrey C;
- Barrow, Magdalena;
- Barton, Edward;
- Bashton, Matthew;
- Bassett, Andrew R;
- Batra, Rahul;
- Baxter, Chris;
- Bayzid, Nadua;
- Beaver, Charlotte;
- Beckett, Angela H;
- Beckwith, Shaun M;
- Bedford, Luke;
- Beer, Robert;
- Beggs, Andrew;
- Bellis, Katherine L;
- Berry, Louise;
- Bertolusso, Beatrice;
- Best, Angus;
- Betteridge, Emma;
- Bibby, David;
- Bicknell, Kelly;
- Binns, Debbie;
- Birchley, Alec;
- Bird, Paul W;
- Bishop, Chloe;
- Blacow, Rachel;
- Blakey, Victoria;
- Blane, Beth;
- Bolt, Frances;
- Bonfield, James;
- Bonner, Stephen;
- Bonsall, David;
- Boswell, Tim;
- Bosworth, Andrew;
- Bourgeois, Yann;
- Boyd, Olivia;
- Bradley, Declan T;
- Breen, Cassie;
- Bresner, Catherine;
- Breuer, Judith;
- Bridgett, Stephen;
- Bronner, Iraad F;
- Brooks, Ellena;
- Broos, Alice;
- Brown, Julianne R;
- Bucca, Giselda;
- Buchan, Sarah L;
- Buck, David;
- Bull, Matthew;
- Burns, Phillipa J;
- Burton-Fanning, Shirelle;
- Byaruhanga, Timothy;
- Byott, Matthew;
- Campbell, Sharon;
- Carabelli, Alessandro M;
- Cargill, James S;
- Carlile, Matthew;
- Carvalho, Silvia F;
- Casey, Anna;
- Castigador, Anibolina;
- Catalan, Jana;
- Chalker, Vicki;
- Chaloner, Nicola J;
- Chand, Meera;
- Chappell, Joseph G;
- Charalampous, Themoula;
- Chatterton, Wendy;
- Chaudhry, Yasmin;
- Churcher, Carol M;
- Clark, Gemma;
- Clarke, Phillip;
- Cogger, Benjamin J;
- Cole, Kevin;
- Collins, Jennifer;
- Colquhoun, Rachel;
- Connor, Thomas R;
- Cook, Kate F;
- Coombes, Jason;
- Corden, Sally;
- Cormie, Claire;
- Cortes, Nicholas;
- Cotic, Marius;
- Cotton, Seb;
- Cottrell, Simon;
- Coupland, Lindsay;
- Cox, MacGregor;
- Cox, Alison;
- Craine, Noel;
- Crawford, Liam;
- Cross, Aidan;
- Crown, Matthew R;
- Crudgington, Dorian;
- Cumley, Nicola;
- Curran, Tanya;
- Curran, Martin D;
- da Silva Filipe, Ana;
- Dabrera, Gavin;
- Darby, Alistair C;
- Davidson, Rose K;
- Davies, Alisha;
- Davies, Robert M;
- Davis, Thomas;
- de Angelis, Daniela;
- De Lacy, Elen;
- de Oliveira Martins, Leonardo;
- Debebe, Johnny;
- Denton-Smith, Rebecca;
- Dervisevic, Samir;
- Dewar, Rebecca;
- Dey, Jayasree;
- Dias, Joana;
- Dobie, Donald;
- Dorman, Matthew J;
- Downing, Fatima;
- Driscoll, Megan;
- du Plessis, Louis;
- Duckworth, Nichola;
- Durham, Jillian;
- Eastick, Kirstine;
- Easton, Lisa J;
- Eccles, Richard;
- Edgeworth, Jonathan;
- Edwards, Sue;
- Bouzidi, Kate El;
- Eldirdiri, Sahar;
- Ellaby, Nicholas;
- Elliott, Scott;
- Eltringham, Gary;
- Ensell, Leah;
- Erkiert, Michelle J;
- Zamudio, Marina Escalera;
- Essex, Sarah;
- Evans, Johnathan M;
- Evans, Cariad;
- Everson, William;
- Fairley, Derek J;
- Fallon, Karlie;
- Fanaie, Arezou;
- Farr, Ben W;
- Fearn, Christopher;
- Feltwell, Theresa;
- Ferguson, Lynne;
- Fina, Laia;
- Flaviani, Flavia;
- Fleming, Vicki M;
- Forrest, Sally;
- Foster-Nyarko, Ebenezer;
- Foulkes, Benjamin H;
- Foulser, Luke;
- Fragakis, Mireille;
- Frampton, Dan;
- Francois, Sarah;
- Fraser, Christophe;
- Freeman, Timothy M;
- Fryer, Helen;
- Fuchs, Marc;
- Fuller, William;
- Gajee, Kavitha;
- Galai, Katerina;
- Gallagher, Abbie;
- Gallagher, Eileen;
- Gallagher, Michael D;
- Gallis, Marta;
- Gaskin, Amy;
- Gatica-Wilcox, Bree;
- Geidelberg, Lily;
- Gemmell, Matthew;
- Georgana, Iliana;
- George, Ryan P;
- Gifford, Laura;
- Gilbert, Lauren;
- Girgis, Sophia T;
- Glaysher, Sharon;
- Goldstein, Emily J;
- Golubchik, Tanya;
- Gomes, Andrea N;
- Gonçalves, Sónia;
- Goodfellow, Ian G;
- Goodwin, Scott;
- Goudarzi, Salman;
- Gourtovaia, Marina;
- Graham, Clive;
- Graham, Lee;
- Grant, Paul R;
- Green, Luke R;
- Green, Angie;
- Greenaway, Jane;
- Gregory, Richard;
- Guest, Martyn;
- Gunson, Rory N;
- Gupta, Ravi K;
- Gutierrez, Bernardo;
- Haldenby, Sam T;
- Hamilton, William L;
- Hansford, Samantha E;
- Haque, Tanzina;
- Harris, Kathryn A;
- Harrison, Ian;
- Harrison, Ewan M;
- Hart, Jennifer;
- Hartley, John A;
- Harvey, William T;
- Harvey, Matthew;
- Hassan-Ibrahim, Mohammed O;
- Heaney, Judith;
- Helmer, Thomas;
- Henderson, John H;
- Hesketh, Andrew R;
- Hey, Jessica;
- Heyburn, David;
- Higginson, Ellen E;
- Hill, Verity;
- Hill, Jack D;
- Hilson, Rachel A;
- Hilvers, Ember;
- Holden, Matthew TG;
- Hollis, Amy;
- Holmes, Christopher W;
- Holmes, Nadine;
- Holmes, Alison H;
- Hopes, Richard;
- Hornsby, Hailey R;
- Hosmillo, Myra;
- Houlihan, Catherine;
- Howson-Wells, Hannah C;
- Hubb, Jonathan;
- Huckson, Hannah;
- Hughes, Warwick;
- Hughes, Joseph;
- Hughes, Margaret;
- Hutchings, Stephanie;
- Idle, Giles;
- Illingworth, Chris J;
- Impey, Robert;
- Irish-Tavares, Dianne;
- Iturriza-Gomara, Miren;
- Izuagbe, Rhys;
- Jackson, Chris;
- Jackson, Ben;
- Jackson, Leigh M;
- Jackson, Kathryn A;
- Jackson, David K;
- Jahun, Aminu S;
- James, Victoria;
- James, Keith;
- Jeanes, Christopher;
- Jeffries, Aaron R;
- Jeremiah, Sarah;
- Jermy, Andrew;
- John, Michaela;
- Johnson, Rob;
- Johnson, Kate;
- Johnston, Ian;
- Jones, Owen;
- Jones, Sophie;
- Jones, Hannah;
- Jones, Christopher R;
- Jones, Neil;
- Joseph, Amelia;
- Judges, Sarah;
- Kay, Gemma L;
- Kay, Sally;
- Keatley, Jon-Paul;
- Keeley, Alexander J;
- Kenyon, Anita;
- Kermack, Leanne M;
- Khakh, Manjinder;
- Kidd, Stephen P;
- Kimuli, Maimuna;
- Kirk, Stuart;
- Kitchen, Christine;
- Kitchman, Katie;
- Knight, Bridget A;
- Koshy, Cherian;
- Kraemer, Moritz UG;
- Kumziene-Summerhayes, Sara;
- Kwiatkowski, Dominic;
- Lackenby, Angie;
- Laing, Kenneth G;
- Lampejo, Temi;
- Langford, Cordelia F;
- Lavin, Deborah;
- Lawton, Andrew I;
- Lee, Jack;
- Lee, David;
- Lensing, Stefanie V;
- Leonard, Steven;
- Levett, Lisa J;
- Le-Viet, Thanh;
- Lewis, Jonathan;
- Lewis, Kevin;
- Liddle, Jennifier;
- Liggett, Steven;
- Lillie, Patrick J;
- Lister, Michelle M;
- Livett, Rich;
- Lo, Stephanie;
- Loman, Nicholas J;
- Loose, Matthew W;
- Louka, Stavroula F;
- Loveson, Katie F;
- Lowdon, Sarah;
- Lowe, Hannah;
- Lowe, Helen L;
- Lucaci, Anita O;
- Ludden, Catherine;
- Lynch, Jessica;
- Lyons, Ronan A;
- Lythgoe, Katrina;
- Machin, Nicholas W;
- MacIntyre-Cockett, George;
- Mack, Andrew;
- Macklin, Ben;
- Maclean, Alasdair;
- Macnaughton, Emily;
- Madona, Pinglawathee;
- Maes, Mailis;
- Maftei, Laurentiu;
- Mahanama, Adhyana IK;
- Mahungu, Tabitha W;
- Mair, Daniel;
- Maksimovic, Joshua;
- Malone, Cassandra S;
- Maloney, Daniel;
- Manesis, Nikos;
- Manley, Robin;
- Mantzouratou, Anna;
- Marchbank, Angela;
- Mariappan, Arun;
- Martincorena, Inigo;
- Nunez, Rocio T Martinez;
- Mather, Alison E;
- Maxwell, Patrick;
- Mayhew, Megan;
- Mbisa, Tamyo;
- McCann, Clare M;
- McCarthy, Shane A;
- McCluggage, Kathryn;
- McClure, Patrick C;
- McCrone, JT;
- McHugh, Martin P;
- McKenna, James P;
- McKerr, Caoimhe;
- McManus, Georgina M;
- McMurray, Claire L;
- McMurray, Claire;
- McNally, Alan;
- Meadows, Lizzie;
- Medd, Nathan;
- Megram, Oliver;
- Menegazzo, Mirko;
- Merrick, Ian;
- Michell, Stephen L;
- Michelsen, Michelle L;
- Mirfenderesky, Mariyam;
- Mirza, Jeremy;
- Miskelly, Julia;
- Moles-Garcia, Emma;
- Moll, Robin J;
- Molnar, Zoltan;
- Monahan, Irene M;
- Mondani, Matteo;
- Mookerjee, Siddharth;
- Moore, Christopher;
- Moore, Jonathan;
- Moore, Nathan;
- Moore, Catherine;
- Morcrette, Helen;
- Morgan, Sian;
- Morgan, Mari;
- Mori, Matilde;
- Morriss, Arthur;
- Moses, Samuel;
- Mower, Craig;
- Muir, Peter;
- Mukaddas, Afrida;
- Munemo, Florence;
- Munn, Robert;
- Murray, Abigail;
- Murray, Leanne J;
- Murray, Darren R;
- Mutingwende, Manasa;
- Myers, Richard;
- Nastouli, Eleni;
- Nebbia, Gaia;
- Nelson, Andrew;
- Nelson, Charlotte;
- Nicholls, Sam;
- Nichols, Jenna;
- Nicodemi, Roberto;
- Nomikou, Kyriaki;
- O’Grady, Justin;
- O'Brien, Sarah;
- Odedra, Mina;
- Ohemeng-Kumi, Natasha;
- Oliver, Karen;
- Orton, Richard J;
- Osman, Husam;
- O'Toole, xeine;
- Pacchiarini, Nicole;
- Padgett, Debra;
- Page, Andrew J;
- Park, Emily J;
- Park, Naomi R;
- Parmar, Surendra;
- Partridge, David G;
- Pascall, David;
- Patel, Amita;
- Patel, Bindi;
- Paterson, Steve;
- Payne, Brendan AI;
- Peacock, Sharon J;
- Pearson, Clare;
- Pelosi, Emanuela;
- Percival, Benita;
- Perkins, Jon;
- Perry, Malorie;
- Pinckert, Malte L;
- Platt, Steven;
- Podplomyk, Olga;
- Pohare, Manoj;
- Pond, Marcus;
- Pope, Cassie F;
- Poplawski, Radoslaw;
- Powell, Jessica;
- Poyner, Jennifer;
- Prestwood, Liam;
- Price, Anna;
- Price, James R;
- Prieto, Jacqui A;
- Pritchard, David T;
- Prosolek, Sophie J;
- Pugh, Georgia;
- Pusok, Monika;
- Pybus, Oliver G;
- Pymont, Hannah M;
- Quail, Michael A;
- Quick, Joshua;
- Radulescu, Clara;
- Raghwani, Jayna;
- Ragonnet-Cronin, Manon;
- Rainbow, Lucille;
- Rajan, Diana;
- Rajatileka, Shavanthi;
- Ramadan, Newara A;
- Rambaut, Andrew;
- Ramble, John;
- Randell, Paul A;
- Randell, Paul;
- Ratcliffe, Liz;
- Raviprakash, Veena;
- Raza, Mohammad;
- Redshaw, Nicholas M;
- Rey, Sara;
- Reynolds, Nicola;
- Richter, Alex;
- Robertson, David L;
- Robinson, Esther;
- Robson, Samuel C;
- Rogan, Fiona;
- Rooke, Stefan;
- Rowe, Will;
- Roy, Sunando;
- Rudder, Steven;
- Ruis, Chris;
- Rushton, Steven;
- Ryan, Felicity;
- Saeed, Kordo;
- Samaraweera, Buddhini;
- Sambles, Christine M;
- Sanderson, Roy;
- Sanderson, Theo;
- Sang, Fei;
- Sass, Thea;
- Scher, Emily;
- Scott, Garren;
- Scott, Carol;
- Sehmi, Jasveen;
- Shaaban, Sharif;
- Shah, Divya;
- Shaw, Jessica;
- Shelest, Ekaterina;
- Shepherd, James G;
- Sheridan, Liz A;
- Sheriff, Nicola;
- Shirley, Lesley;
- Sillitoe, John;
- Silviera, Siona;
- Simpson, David A;
- Singh, Aditi;
- Singleton, Dawn;
- Skvortsov, Timofey;
- Sloan, Tim J;
- Sluga, Graciela;
- Smith, Ken;
- Smith, Kim S;
- Smith, Perminder;
- Smith, Darren L;
- Smith, Louise;
- Smith, Colin P;
- Smith, Nikki;
- Smollett, Katherine L;
- Snell, Luke B;
- Somassa, Thomas;
- Southgate, Joel;
- Spellman, Karla;
- Chapman, Michael H Spencer;
- Spurgin, Lewis G;
- Spyer, Moira J;
- Stanley, Rachael;
- Stanley, William;
- Stanton, Thomas D;
- Starinskij, Igor;
- Stockton, Joanne;
- Stonehouse, Susanne;
- Storey, Nathaniel;
- Studholme, David J;
- Sudhanva, Malur;
- Swindells, Emma;
- Taha, Yusri;
- Tan, Ngee Keong;
- Tang, Julian W;
- Tang, Miao;
- Taylor, Ben EW;
- Taylor, Joshua F;
- Taylor, Sarah;
- Temperton, Ben;
- Templeton, Kate E;
- Thomas, Claire;
- Thomson, Laura;
- Thomson, Emma C;
- Thornton, Alicia;
- Thurston, Scott AJ;
- Todd, John A;
- Tomb, Rachael;
- Tong, Lily;
- Tonkin-Hill, Gerry;
- Torok, M Estee;
- Tovar-Corona, Jaime M;
- Trebes, Amy;
- Trotter, Alexander J;
- Tsatsani, Ioulia;
- Turnbull, Robyn;
- Twohig, Katherine A;
- Umpleby, Helen;
- Underwood, Anthony P;
- Vamos, Edith E;
- Vasylyeva, Tetyana I;
- Vattipally, Sreenu;
- Vernet, Gabrielle;
- Vipond, Barry B;
- Volz, Erik M;
- Walsh, Sarah;
- Wang, Dennis;
- Warne, Ben;
- Warwick-Dugdale, Joanna;
- Wastnedge, Elizabeth;
- Watkins, Joanne;
- Watson, Louisa K;
- Waugh, Sheila;
- Webster, Hermione J;
- Weldon, Danni;
- Westwick, Elaine;
- Whalley, Thomas;
- Wheeler, Helen;
- Whitehead, Mark;
- Whiteley, Max;
- Whitwham, Andrew;
- Wierzbicki, Claudia;
- Willford, Nicholas J;
- Williams, Lesley-Anne;
- Williams, Rebecca;
- Williams, Cheryl;
- Williams, Chris;
- Williams, Charlotte A;
- Williams, Rachel J;
- Williams, Thomas;
- Williams, Catryn;
- Williamson, Kathleen A;
- Wilson-Davies, Eleri;
- Witele, Eric;
- Withell, Karen T;
- Witney, Adam A;
- Wolverson, Paige;
- Wong, Nick;
- Workman, Trudy;
- Wright, Victoria;
- Wright, Derek W;
- Wyatt, Tim;
- Wyllie, Sarah;
- Xu-McCrae, Li;
- Yavus, Mehmet;
- Yaze, Geraldine;
- Yeats, Corin A;
- Yebra, Gonzalo;
- Yew, Wen C;
- Young, Gregory R;
- Young, Jamie;
- Zarebski, Alex E;
- Zhang, Peijun;
- Maini, Mala K;
- Ogg, Graham;
- Knight, Julian C;
- Baillie, J Kenneth;
- Semple, Malcolm G;
- Openshaw, Peter JM;
- Carson, Gail;
- Alex, Beatrice;
- Andrikopoulos, Petros;
- Bach, Benjamin;
- Barclay, Wendy S;
- Bogaert, Debby;
- Chand, Meera;
- Chechi, Kanta;
- Cooke, Graham S;
- da Silva Filipe, Ana;
- Docherty, Annemarie B;
- dos Santos Correia, Gonçalo;
- Dumas, Marc-Emmanuel;
- Dunning, Jake;
- Fletcher, Tom;
- Green, Christopher A;
- Greenhalf, William;
- Griffin, Julian L;
- Gupta, Rishi K;
- Harrison, Ewen M;
- Hiscox, Julian A;
- Ho, Antonia Ying Wai;
- Horby, Peter W;
- Ijaz, Samreen;
- Khoo, Saye;
- Klenerman, Paul;
- Law, Andrew;
- Lewis, Matthew R;
- Liggi, Sonia;
- Lim, Wei Shen;
- Maslen, Lynn;
- Mentzer, Alexander J;
- Merson, Laura;
- Meynert, Alison M;
- Noursadeghi, Mahdad;
- Olanipekun, Michael;
- Osagie, Anthonia;
- Palmarini, Massimo;
- Palmieri, Carlo;
- Paxton, William A;
- Pollakis, Georgios;
- Price, Nicholas;
- Rambaut, Andrew;
- Robertson, David L;
- Russell, Clark D;
- Sancho-Shimizu, Vanessa;
- Sands, Caroline J;
- Scott, Janet T;
- Sigfrid, Louise;
- Solomon, Tom;
- Sriskandan, Shiranee;
- Stuart, David;
- Summers, Charlotte;
- Swann, Olivia V;
- Takats, Zoltan;
- Takis, Panteleimon;
- Tedder, Richard S;
- Thompson, AA Roger;
- Thomson, Emma C;
- Thwaites, Ryan S;
- Zambon, Maria;
- Hardwick, Hayley;
- Donohue, Chloe;
- Griffiths, Fiona;
- Oosthuyzen, Wilna;
- Donegan, Cara;
- Spencer, Rebecca G;
- Dalton, Jo;
- Girvan, Michelle;
- Saviciute, Egle;
- Roberts, Stephanie;
- Harrison, Janet;
- Marsh, Laura;
- Connor, Marie;
- Halpin, Sophie;
- Jackson, Clare;
- Gamble, Carrol;
- Plotkin, Daniel;
- Lee, James;
- Leeming, Gary;
- Law, Andrew;
- Wham, Murray;
- Clohisey, Sara;
- Hendry, Ross;
- Scott-Brown, James;
- Shaw, Victoria;
- McDonald, Sarah E;
- Keating, Seán;
- Ahmed, Katie A;
- Armstrong, Jane A;
- Ashworth, Milton;
- Asiimwe, Innocent G;
- Bakshi, Siddharth;
- Barlow, Samantha L;
- Booth, Laura;
- Brennan, Benjamin;
- Bullock, Katie;
- Catterall, Benjamin WA;
- Clark, Jordan J;
- Clarke, Emily A;
- Cole, Sarah;
- Cooper, Louise;
- Cox, Helen;
- Davis, Christopher;
- Dincarslan, Oslem;
- Dunn, Chris;
- Dyer, Philip;
- Elliott, Angela;
- Evans, Anthony;
- Finch, Lorna;
- Fisher, Lewis WS;
- Foster, Terry;
- Garcia-Dorival, Isabel;
- Gunning, Philip;
- Hartley, Catherine;
- Jensen, Rebecca L;
- Jones, Christopher B;
- Jones, Trevor R;
- Khandaker, Shadia;
- King, Katharine;
- Kiy, Robyn T;
- Koukorava, Chrysa;
- Lake, Annette;
- Lant, Suzannah;
- Latawiec, Diane;
- Lavelle-Langham, Lara;
- Lefteri, Daniella;
- Lett, Lauren;
- Livoti, Lucia A;
- Mancini, Maria;
- McDonald, Sarah;
- McEvoy, Laurence;
- McLauchlan, John;
- Metelmann, Soeren;
- Miah, Nahida S;
- Middleton, Joanna;
- Mitchell, Joyce;
- Moore, Shona C;
- Murphy, Ellen G;
- Penrice-Randal, Rebekah;
- Pilgrim, Jack;
- Prince, Tessa;
- Reynolds, Will;
- Ridley, P Matthew;
- Sales, Debby;
- Shaw, Victoria E;
- Shears, Rebecca K;
- Small, Benjamin;
- Subramaniam, Krishanthi S;
- Szemiel, Agnieska;
- Taggart, Aislynn;
- Tanianis-Hughes, Jolanta;
- Thomas, Jordan;
- Trochu, Erwan;
- van Tonder, Libby;
- Wilcock, Eve;
- Zhang, J Eunice;
- Flaherty, Lisa;
- Maziere, Nicole;
- Cass, Emily;
- Carracedo, Alejandra Doce;
- Carlucci, Nicola;
- Holmes, Anthony;
- Massey, Hannah;
- Murphy, Lee;
- Wrobel, Nicola;
- McCafferty, Sarah;
- Morrice, Kirstie;
- MacLean, Alan;
- Adeniji, Kayode;
- Agranoff, Daniel;
- Agwuh, Ken;
- Ail, Dhiraj;
- Aldera, Erin L;
- Alegria, Ana;
- Allen, Sam;
- Angus, Brian;
- Ashish, Abdul;
- Atkinson, Dougal;
- Bari, Shahedal;
- Barlow, Gavin;
- Barnass, Stella;
- Barrett, Nicholas;
- Bassford, Christopher;
- Basude, Sneha;
- Baxter, David;
- Beadsworth, Michael;
- Bernatoniene, Jolanta;
- Berridge, John;
- Berry, Colin;
- Best, Nicola;
- Bothma, Pieter;
- Chadwick, David;
- Brittain-Long, Robin;
- Bulteel, Naomi;
- Burden, Tom;
- Burtenshaw, Andrew;
- Caruth, Vikki;
- Chadwick, David;
- Chambler, Duncan;
- Chee, Nigel;
- Child, Jenny;
- Chukkambotla, Srikanth;
- Clark, Tom;
- Collini, Paul;
- Cosgrove, Catherine;
- Cupitt, Jason;
- Cutino-Moguel, Maria-Teresa;
- Dark, Paul;
- Dawson, Chris;
- Dervisevic, Samir;
- Donnison, Phil;
- Douthwaite, Sam;
- Drummond, Andrew;
- DuRand, Ingrid;
- Dushianthan, Ahilanadan;
- Dyer, Tristan;
- Evans, Cariad;
- Eziefula, Chi;
- Fegan, Chrisopher;
- Finn, Adam;
- Fullerton, Duncan;
- Garg, Sanjeev;
- Garg, Sanjeev;
- Garg, Atul;
- Gkrania-Klotsas, Effrossyni;
- Godden, Jo;
- Goldsmith, Arthur;
- Graham, Clive;
- Hardy, Elaine;
- Hartshorn, Stuart;
- Harvey, Daniel;
- Havalda, Peter;
- Hawcutt, Daniel B;
- Hobrok, Maria;
- Hodgson, Luke;
- Hormis, Anil;
- Jacobs, Michael;
- Jain, Susan;
- Jennings, Paul;
- Kaliappan, Agilan;
- Kasipandian, Vidya;
- Kegg, Stephen;
- Kelsey, Michael;
- Kendall, Jason;
- Kerrison, Caroline;
- Kerslake, Ian;
- Koch, Oliver;
- Koduri, Gouri;
- Koshy, George;
- Laha, Shondipon;
- Laird, Steven;
- Larkin, Susan;
- Leiner, Tamas;
- Lillie, Patrick;
- Limb, James;
- Linnett, Vanessa;
- Little, Jeff;
- Lyttle, Mark;
- MacMahon, Michael;
- MacNaughton, Emily;
- Mankregod, Ravish;
- Masson, Huw;
- Matovu, Elijah;
- McCullough, Katherine;
- McEwen, Ruth;
- Meda, Manjula;
- Mills, Gary;
- Minton, Jane;
- Mirfenderesky, Mariyam;
- Mohandas, Kavya;
- Mok, Quen;
- Moon, James;
- Moore, Elinoor;
- Morgan, Patrick;
- Morris, Craig;
- Mortimore, Katherine;
- Moses, Samuel;
- Mpenge, Mbiye;
- Mulla, Rohinton;
- Murphy, Michael;
- Nagel, Megan;
- Nagarajan, Thapas;
- Nelson, Mark;
- Norris, Lillian;
- O'Shea, Matthew K;
- Otahal, Igor;
- Ostermann, Marlies;
- Pais, Mark;
- Palmieri, Carlo;
- Panchatsharam, Selva;
- Papakonstantinou, Danai;
- Paraiso, Hassan;
- Patel, Brij;
- Pattison, Natalie;
- Pepperell, Justin;
- Peters, Mark;
- Phull, Mandeep;
- Pintus, Stefania;
- Pooni, Jagtur Singh;
- Planche, Tim;
- Post, Frank;
- Price, David;
- Prout, Rachel;
- Rae, Nikolas;
- Reschreiter, Henrik;
- Reynolds, Tim;
- Richardson, Neil;
- Roberts, Mark;
- Roberts, Devender;
- Rose, Alistair;
- Rousseau, Guy;
- Ruge, Bobby;
- Ryan, Brendan;
- Saluja, Taranprit;
- Schmid, Matthias L;
- Shah, Aarti;
- Shanmuga, Prad;
- Sharma, Anil;
- Shawcross, Anna;
- Sizer, Jeremy;
- Shankar-Hari, Manu;
- Smith, Richard;
- Snelson, Catherine;
- Spittle, Nick;
- Staines, Nikki;
- Stambach, Tom;
- Stewart, Richard;
- Subudhi, Pradeep;
- Szakmany, Tamas;
- Tatham, Kate;
- Thomas, Jo;
- Thompson, Chris;
- Thompson, Robert;
- Tridente, Ascanio;
- Tupper-Carey, Darell;
- Twagira, Mary;
- Vallotton, Nick;
- Vancheeswaran, Rama;
- Vincent-Smith, Lisa;
- Visuvanathan, Shico;
- Vuylsteke, Alan;
- Waddy, Sam;
- Wake, Rachel;
- Walden, Andrew;
- Welters, Ingeborg;
- Whitehouse, Tony;
- Whittaker, Paul;
- Whittington, Ashley;
- Papineni, Padmasayee;
- Wijesinghe, Meme;
- Williams, Martin;
- Wilson, Lawrence;
- Cole, Sarah;
- Winchester, Stephen;
- Wiselka, Martin;
- Wolverson, Adam;
- Wootton, Daniel G;
- Workman, Andrew;
- Yates, Bryan;
- Young, Peter;
- Peng, Yanchun;
- Rowland-Jones, Sarah L;
- Dong, Tao
- et al.
Published Web Location
https://doi.org/10.1016/j.isci.2021.103353Abstract
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%