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Seizure proneness and neurotransmitter uptake
Published Web Location
https://doi.org/10.1007/bf00964472Abstract
The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine has been examined. The high-affinity transport mechanisms toward glutamate, GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA/2IBG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBG mice. However, no difference in the density of muscarinic binding sites in the two mouse strains was found.
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