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The effect of prolonged tracheal intubation on the association between patent ductus arteriosus and bronchopulmonary dysplasia (grades 2 and 3).
Published Web Locationhttps://doi.org/10.1038/s41372-020-0718-x
ObjectiveTo determine if the need for mechanical ventilation alters the association between prolonged patent ductus arteriosus (PDA) exposure and bronchopulmonary dysplasia (grades 2 and 3) (BPD).
Study designObservational study of 407 infants (<28 weeks' gestation) with echocardiograms performed at planned intervals.
ResultsTwelve percent (48/407) of study infants had BPD (grades 2 and 3). In a multivariable regression model, exposure to a moderate-to-large PDA shunt for ≥7 days was associated with an increased risk of BPD (grades 2 and 3) (from 16 to 35%: aRD = 19% (6, 32%), p < 0.005) when infants required ≥10 days of intubation (n = 170). In contrast, there was no significant association between prolonged PDA exposure and BPD when infants required ≤9 days of intubation (aRD = 4%) (-1, 10%) (n = 237).
ConclusionsModerate-to-large PDAs are associated with an increased risk of BPD-but only when infants require intubation ≥10 days.
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