Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules.
- Author(s): Focken, Thilo
- Hanessian, Stephen
- et al.
Published Web Locationhttps://doi.org/10.3762/bjoc.10.195
A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphonamide anions in asymmetric alkylations, Michael additions, olefinations, and cyclopropanations will be summarized, as well as an overview of the synthesis of the employed phosphonamide reagents.