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Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline - Volume 29, Number 1—January 2023 - Emerging Infectious Diseases journal - CDC
- Spottiswoode, Natasha;
- Pet, Douglas;
- Kim, Annie;
- Gruenberg, Katherine;
- Shah, Maulik;
- Ramachandran, Amrutha;
- Laurie, Matthew T;
- Zia, Maham;
- Fouassier, Camille;
- Boutros, Christine L;
- Lu, Rufei;
- Zhang, Yueyuan;
- Servellita, Venice;
- Bollen, Andrew;
- Chiu, Charles Y;
- Wilson, Michael R;
- Valdivia, Liza;
- DeRisi, Joseph L
- et al.
Published Web Location
https://doi.org/10.3201/eid2901.221531Abstract
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.
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