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Cancer specific survival in patients with sickle cell disease.

  • Author(s): Brunson, Ann;
  • Keegan, Theresa HM;
  • Mahajan, Anjlee;
  • Paulukonis, Susan;
  • Wun, Ted
  • et al.

Published Web Location

https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15687
No data is associated with this publication.
Abstract

Sickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state-wide hospitalisation data, were linked to the California Cancer Registry (1988-2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3-fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer-specific survival, suggesting that SCD cancer patients should be treated with similar therapeutic intent.

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