Skip to main content
eScholarship
Open Access Publications from the University of California

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

  • Author(s): Cohen, NR
  • Brennan, PJ
  • Shay, T
  • Watts, GF
  • Brigl, M
  • Kang, J
  • Brenner, MB
  • Monach, P
  • Shinton, SA
  • Hardy, RR
  • Jianu, R
  • Koller, D
  • Collins, J
  • Gazit, R
  • Garrison, BS
  • Rossi, DJ
  • Narayan, K
  • Sylvia, K
  • Fletcher, A
  • Elpek, K
  • Bellemare-Pelletier, A
  • Malhotra, D
  • Turley, S
  • Best, AJ
  • Knell, J
  • Goldrath, A
  • Jojic, V
  • Koller, D
  • Regev, A
  • Cohan, N
  • Brennen, P
  • Brennar, M
  • Kreslavsky, T
  • Bezman, NA
  • Sun, JC
  • Kim, CC
  • Lanier, LL
  • Miller, J
  • Brown, B
  • Merad, M
  • Gautier, EL
  • Jakubzick, C
  • Randolph, GJ
  • Kim, F
  • Rao, TN
  • Wagers, A
  • Heng, T
  • Painter, M
  • Ericson, J
  • Davis, S
  • Ergun, A
  • Mingueneau, M
  • Mathis, D
  • Benoist, C
  • et al.

Published Web Location

https://doi.org/10.1038/ni.2490
Abstract

Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in γδ T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes. © 2013 Nature America, Inc. All rights reserved.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View