Alberts, Catharina J; Heard, Isabelle; Canestri, Ana; Marchand, Lucie; Fléjou, Jean-François; Piroth, Lionel; Ferry, Tristan; Didelot, Jean-Michel; Siproudhis, Laurent; Henno, Sébastien; Poizot-Martin, Isabelle; Darragh, Teresa M; Clifford, Gary M; Combes, Jean-Damien; Etienney, Isabelle; Arvieux, C; Canestri, A; Clifford, GM; Combes, JD; Costes-Martineau, V; Del Grande, J; Didelot, JM; Etienney, I; Falguières, M; Ferry, T; Fischer, H; Flejou, JF; Heard, I; Henno, S; Hoyau, N; Landon, M; Laude, H; Le Breton, F; Lesage, AC; Lion, A; Maincent, G; Marchand, L; Njatonirina, H; Patey, O; Petrov Sanchez, V; Pialoux, V; Piroth, L; Poizot-Martin, I; Zaegel-Faucher, O; Ressiot, E; Radenne, S; Reynes, J; Siproudhis, L; Tamalet, C; Tattevin, P

doi:10.1093/infdis/jiz623

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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France.

Published Web Location

https://doi.org/10.1093/infdis/jiz623

Abstract

Background

Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM).

Methods

We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018).

Results

Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months).

Conclusions

In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.

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