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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France
- Alberts, Catharina J;
- Heard, Isabelle;
- Canestri, Ana;
- Marchand, Lucie;
- Fléjou, Jean-François;
- Piroth, Lionel;
- Ferry, Tristan;
- Didelot, Jean-Michel;
- Siproudhis, Laurent;
- Henno, Sébastien;
- Poizot-Martin, Isabelle;
- Darragh, Teresa M;
- Clifford, Gary M;
- Combes, Jean-Damien;
- Etienney, Isabelle;
- Arvieux, C;
- Canestri, A;
- Clifford, GM;
- Combes, JD;
- Costes-Martineau, V;
- Del Grande, J;
- Didelot, JM;
- Etienney, I;
- Falguières, M;
- Ferry, T;
- Fischer, H;
- Flejou, JF;
- Heard, I;
- Henno, S;
- Hoyau, N;
- Landon, M;
- Laude, H;
- Le Breton, F;
- Lesage, AC;
- Lion, A;
- Maincent, G;
- Marchand, L;
- Njatonirina, H;
- Patey, O;
- Sanchez, V Petrov;
- Pialoux, V;
- Piroth, L;
- Poizot-Martin, I;
- Zaegel-Faucher, O;
- Ressiot, E;
- Radenne, S;
- Reynes, J;
- Siproudhis, L;
- Tamalet, C;
- Tattevin, P
Published Web Location
https://doi.org/10.1093/infdis/jiz623Abstract
BACKGROUND: Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS: We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). RESULTS: Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). CONCLUSIONS: In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
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