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Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France.

  • Author(s): Alberts, Catharina J;
  • Heard, Isabelle;
  • Canestri, Ana;
  • Marchand, Lucie;
  • Fléjou, Jean-François;
  • Piroth, Lionel;
  • Ferry, Tristan;
  • Didelot, Jean-Michel;
  • Siproudhis, Laurent;
  • Henno, Sébastien;
  • Poizot-Martin, Isabelle;
  • Darragh, Teresa M;
  • Clifford, Gary M;
  • Combes, Jean-Damien;
  • Etienney, Isabelle;
  • ANRS EP57 APACHES Study group
  • et al.
Abstract

Background

Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM).

Methods

We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018).

Results

Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months).

Conclusions

In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.

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