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Expression of miR-124 inhibits growth of medulloblastoma cells

  • Author(s): Silber, J
  • Hashizume, R
  • Felix, T
  • Hariono, S
  • Yu, M
  • Berger, MS
  • Huse, JT
  • Vandenberg, SR
  • David James, C
  • Graeme Hodgson, J
  • Gupta, N
  • et al.
Abstract

Medulloblastoma is the most common malignant brain tumor in children, and a substantial number of patients die as a result of tumor progression. Overexpression of CDK6 is present in approximately one-third of medulloblastomas and is an independent poor prognostic marker for this disease. MicroRNA (miR)-124 inhibits expression of CDK6 and prevents proliferation of glioblastoma and medulloblastoma cells in vitro. We examined the effects of miR-124 overexpression on medulloblastoma cells both in vitro and in vivo and compared cell lines that have low and high CDK6 expression. MiR-124 overexpression inhibits the proliferation of medulloblastoma cells, and this effect is mediated mostly through the action of miR-124 upon CDK6. We further show that induced expression of miR-124 potently inhibits growth of medulloblastoma xenograft tumors in rodents. Further testing of miR-124 will help define the ultimate therapeutic potential of preclinical models of medulloblastoma in conjunction with various delivery strategies for treatment. © 2012 The Author(s).

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