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Open Access Publications from the University of California

Methylphenidate enhances acquisition and retention of spatial memory

  • Author(s): Carmack, SA
  • Block, CL
  • Howell, KK
  • Anagnostaras, SG
  • et al.

Psychostimulants containing methylphenidate (MPH) are increasingly being used both on and off-label to enhance learning and memory. Still, almost no studies have investigated MPH's ability to specifically improve spatial or long-term memory. Here we examined the effect of training with 1 or 10. mg/kg MPH on hidden platform learning in the Morris water maze. 10. mg/kg MPH improved memory acquisition and retention, while 1. mg/kg MPH improved memory retention. Taken together with prior evidence that low, clinically relevant, doses of MPH (0.01-1. mg/kg MPH) enhance fear memory we conclude that MPH broadly enhances memory. © 2014 Elsevier Ireland Ltd.

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