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Efficacy of Multi-Modal Migraine Prophylaxis Therapy on Hyperacusis Patients.

  • Author(s): Abouzari, Mehdi;
  • Tan, Donald;
  • Sarna, Brooke;
  • Ghavami, Yaser;
  • Goshtasbi, Khodayar;
  • Parker, Erica M;
  • Lin, Harrison W;
  • Djalilian, Hamid R
  • et al.
Abstract

Objectives

To evaluate the efficacy of a multi-modal migraine prophylaxis therapy for patients with hyperacusis.

Methods

In a prospective cohort, patients with hyperacusis were treated with a multi-modal step-wise migraine prophylactic regimen (nortriptyline, verapamil, topiramate, or a combination thereof) as well as lifestyle and dietary modifications. Pre- and post-treatment average loudness discomfort level (LDL), hyperacusis discomfort level measured by a visual analogue scale (VAS), and scores on the modified Khalfa questionnaire for severity of hyperacusis were compared.

Results

Twenty-two of the 25 patients (88%) reported subjective resolution of their symptoms following treatment. Post-treatment audiograms showed significant improvement in average LDL from 81.3 ± 3.2 dB to 86.4 ± 2.6 dB (P < .001), indicating increased sound tolerability. The VAS discomfort level also showed significant improvement from a pre-treatment average of 7.7 ± 1.1 to 3.7 ± 1.6 post-treatment (P < .001). There was also significant improvement in the average total score on modified Khalfa questionnaire (32.2 ± 3.6 vs 22.0 ± 5.7, P < .001).

Conclusions

The majority of patients with hyperacusis demonstrated symptomatic improvement from migraine prophylaxis therapy, as indicated by self-reported and audiometric measures. Our findings indicate that, for some patients, hyperacusis may share a pathophysiologic basis with migraine disorder and may be successfully managed with multimodal migraine prophylaxis therapy.

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