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Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy.

  • Author(s): Wilson, David
  • Abbotts, R
  • Jewell, R
  • Nsengimana, J
  • Maloney, DJ
  • Simeonov, A
  • Seedhouse, C
  • Elliott, F
  • Laye, J
  • Walker, C
  • Jadhav, A
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4102809?pdf=render
No data is associated with this publication.
Abstract

Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer. We have developed small molecule inhibitors against APE1 repair nuclease activi

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