Metabolic and thermal stimuli control K 2P 2.1 (TREK-1) through modular sensory and gating domains
- Author(s): Minor, Daniel
- Bagriantsev, SN
- Clark, KA
- Minor, DL
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3411076?pdf=render
K 2P 2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that responds to external pH, GPCR-mediated phosphorylation signals, and temperature through the action of distinct sensors within the channel. How the various intracellular and extrac