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Metabolic and thermal stimuli control K 2P 2.1 (TREK-1) through modular sensory and gating domains

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K 2P 2.1 (TREK-1) is a polymodal two-pore domain leak potassium channel that responds to external pH, GPCR-mediated phosphorylation signals, and temperature through the action of distinct sensors within the channel. How the various intracellular and extrac

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