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Open Access Publications from the University of California

Fast quantitative 3D ultrashort echo time MRI of cortical bone using extended cones sampling.

  • Author(s): Wan, Lidi
  • Zhao, Wei
  • Ma, Yajun
  • Jerban, Saeed
  • Searleman, Adam C
  • Carl, Michael
  • Chang, Eric Y
  • Tang, Guangyu
  • Du, Jiang
  • et al.

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PURPOSE:To investigate the effect of stretching sampling window on quantitative 3D ultrashort TE (UTE) imaging of cortical bone at 3 T. METHODS:Ten bovine cortical bone and 17 human tibial midshaft samples were imaged with a 3T clinical MRI scanner using an 8-channel knee coil. Quantitative 3D UTE imaging biomarkers, including T1 , T2∗ , magnetization transfer ratio and magnetization transfer modeling, were performed using radial or spiral Cones sampling trajectories with various durations. Errors in UTE-MRI biomarkers as a function of sampling time were evaluated using radial sampling as a reference standard. RESULTS:For both bovine and human cortical bone samples, no significant differences were observed for all UTE biomarkers (single-component T2∗ , bicomponent T2∗ and relative fractions, T1 , magnetization transfer ratio, and magnetization transfer modeling of macromolecular fraction) for spiral sampling windows of 992 µs to 1600 µs compared with a radial sampling window of 688 µs. CONCLUSION:The total scan time can be reduced by 76% with quantification errors less than 5%. Quantitative UTE-MRI techniques can be greatly accelerated using longer sampling windows without significant quantification errors.

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