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Two Methods for Selective Deprotection of Diphenylmethylsilyl Protecting Group under Aqueous Conditions

Abstract

Two Methods for Selective Deprotection of Diphenylmethylsilyl Protecting Group under Aqueous Conditions

By

Joshua A. Lieberman

Two, new, methods for chemo-selective deprotection of diphenylmethylsilylether of allylic, benzylic, and alkyl alcohols is achieved. Catalytic amounts of Perfluoro-1-butanesulfonyl fluoride or stoichiometric amounts of 18-crown-6 ether are employed for successful deprotection. All selective deprotection can be attained under mild aqueous conditions.

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