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Two Methods for Selective Deprotection of Diphenylmethylsilyl Protecting Group under Aqueous Conditions

  • Author(s): Lieberman, Josh
  • Advisor(s): Lipshutz, Bruce H.
  • et al.
Abstract

Two Methods for Selective Deprotection of Diphenylmethylsilyl Protecting Group under Aqueous Conditions

By

Joshua A. Lieberman

Two, new, methods for chemo-selective deprotection of diphenylmethylsilylether of allylic, benzylic, and alkyl alcohols is achieved. Catalytic amounts of Perfluoro-1-butanesulfonyl fluoride or stoichiometric amounts of 18-crown-6 ether are employed for successful deprotection. All selective deprotection can be attained under mild aqueous conditions.

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