Genetically encoding an electrophilic amino acid for protein stapling and covalent binding to native receptors
- Author(s): Wang, Lei
- Chen, XH
- Xiang, Z
- Hu, YS
- Lacey, VK
- Cang, H
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4168779?pdf=render
© 2014 American Chemical Society.Covalent bonds can be generated within and between proteins by an unnatural amino acid (Uaa) reacting with a natural residue through proximity-enabled bioreactivity. Until now, Uaas have been developed to react mainly with
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