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Genetically encoding an electrophilic amino acid for protein stapling and covalent binding to native receptors

  • Author(s): Wang, Lei
  • Chen, XH
  • Xiang, Z
  • Hu, YS
  • Lacey, VK
  • Cang, H
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4168779?pdf=render
No data is associated with this publication.
Abstract

© 2014 American Chemical Society.Covalent bonds can be generated within and between proteins by an unnatural amino acid (Uaa) reacting with a natural residue through proximity-enabled bioreactivity. Until now, Uaas have been developed to react mainly with

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