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Open Access Publications from the University of California

Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player.

  • Author(s): Grinberg, Lea T
  • Anghinah, Renato
  • Nascimento, Camila Fernandes
  • Amaro, Edson
  • Leite, Renata P
  • Martin, Maria da Graça M
  • Naslavsky, Michel S
  • Takada, Leonel T
  • Filho, Wilson Jacob
  • Pasqualucci, Carlos A
  • Nitrini, Ricardo
  • et al.

The relationship between soccer and chronic traumatic encephalopathy (CTE) is not well established. We report clinicopathological correlations in an 83-year-old retired center-back soccer player, with no history of concussion, manifesting typical Alzheimer-type dementia. Examination revealed mixed pathology including widespread CTE, moderate Alzheimer's disease, hippocampal sclerosis, and TDP-43 proteinopathy. This case adds to a few CTE cases described in soccer players. Furthermore, it corroborates that CTE may present clinically as typical Alzheimer-type dementia. Further studies investigating the extent to which soccer is a risk for CTE are needed.

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