Plasma membrane calcium ATPase regulates bone mass by fine-tuning osteoclast differentiation and survival
- Author(s): Pearce, David
- Bhargava, Aditi
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3529522?pdf=render
The precise regulation of Ca2+ dynamics is crucial for proper differentiation and function of osteoclasts. Here we show the involvement of plasma membrane Ca2+ ATPase (PMCA) isoforms 1 and 4 in osteoclastogenesis. In immature/undifferentiated cells, PMCAs