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DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation
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https://doi.org/10.1083/jcb.201803037Abstract
Carroll et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201708023) developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation.
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