Skip to main content
Open Access Publications from the University of California


UCLA Previously Published Works bannerUCLA

DNA replication licensing in stem cells: Gatekeeping the commitment to proliferation.

  • Author(s): Coller, Hilary A
  • et al.

Carroll et al. (2018. J. Cell Biol. developed a method to assess DNA replication licensing in tissues. They show that intestinal stem cells within wild-type crypts, but not in crypts with cancer-causing mutations, are largely unlicensed, suggesting that licensing may represent a rate-limiting step in the commitment to proliferation.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View