Lawrence Berkeley National Laboratory
A prominent large high-density lipoprotein at birth enriched in apolipoprotein C-I
identifies a new group of infancts of lower birth weight and younger gestational age
- Author(s): Kwiterovich Jr., Peter O.
- Cockrill, Steven L.
- Virgil, Donna G.
- Garrett, Elizabeth
- Otvos, James
- Knight-Gibson, Carolyn
- Alaupovic, Petar
- Forte, Trudy
- Farwig, Zachlyn N.
- Macfarlane, Ronald D.
- et al.
Because low birth weight is associated with adverse cardiovascular risk and death in adults, lipoprotein heterogeneity at birth was studied. A prominent, large high-density lipoprotein (HDL) subclass enriched in apolipoprotein C-I (apoC-I) was found in 19 percent of infants, who had significantly lower birth weights and younger gestational ages and distinctly different lipoprotein profiles than infants with undetectable, possible or probable amounts of apoC-I-enriched HDL. An elevated amount of an apoC-I-enriched HDL identifies a new group of low birth weight infants.