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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
- Author(s): Wiencke, John
- MacHiela, MJ
- Zhou, W
- Karlins, E
- Sampson, JN
- Freedman, ND
- Yang, Q
- Hicks, B
- Dagnall, C
- Hautman, C
- Jacobs, KB
- et al.
Published Web Location
http://europepmc.org/articles/PMC4909985?pdf=renderNo data is associated with this publication.
Abstract
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.2
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