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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

  • Author(s): Wiencke, John;
  • MacHiela, MJ;
  • Zhou, W;
  • Karlins, E;
  • Sampson, JN;
  • Freedman, ND;
  • Yang, Q;
  • Hicks, B;
  • Dagnall, C;
  • Hautman, C;
  • Jacobs, KB
  • et al.

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To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.2

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