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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

  • Author(s): Wiencke, John
  • MacHiela, MJ
  • Zhou, W
  • Karlins, E
  • Sampson, JN
  • Freedman, ND
  • Yang, Q
  • Hicks, B
  • Dagnall, C
  • Hautman, C
  • Jacobs, KB
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4909985?pdf=render
No data is associated with this publication.
Abstract

To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.2

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