Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations
- Author(s): Giacomini, Kathleen
- Hsu, V
- Vieira, MDLT
- Zhao, P
- Zhang, L
- Zheng, JH
- Nordmark, A
- Berglund, EG
- Giacomini, KM
- Huang, SM
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3927056?pdf=render
Background and Objectives: The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. Howev
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