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Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations

  • Author(s): Giacomini, Kathleen
  • Hsu, V
  • Vieira, MDLT
  • Zhao, P
  • Zhang, L
  • Zheng, JH
  • Nordmark, A
  • Berglund, EG
  • Giacomini, KM
  • Huang, SM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3927056?pdf=render
No data is associated with this publication.
Abstract

Background and Objectives: The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. Howev

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