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Open Access Publications from the University of California

Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations

  • Author(s): Giacomini, Kathleen
  • Hsu, V
  • Vieira, MDLT
  • Zhao, P
  • Zhang, L
  • Zheng, JH
  • Nordmark, A
  • Berglund, EG
  • Giacomini, KM
  • Huang, SM
  • et al.

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Background and Objectives: The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. Howev

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