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Open Access Publications from the University of California

Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

  • Author(s): Criswell, Lindsey
  • McCune, Joseph
  • Sacre, K
  • Criswell, LA
  • McCune, JM
  • et al.

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Introduction: Plasmacytoid dendritic cells (pDCs) constitutively express two members of the Toll-like receptor (TLR) family, TLR-9 and TLR-7, through which they can be stimulated to produce high levels of interferon (IFN)-α, a key mediator of the pathogene

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