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Open Access Publications from the University of California

Rational design of molecular rotors as beta amyloid binding agents and viscosity sensors

  • Author(s): Chang, Willy M.
  • et al.
Abstract

A new family of fluorescent markers, also known as molecular rotors, containing an Amino Naphthalenyl-2-Cyano -Acrylate (ANCA) motif has been synthesized and evaluated for its capability to associate with aggregated [beta]- amyloid (AP) peptides. Chemical modifications were introduced to explore their effect on the capability of the ANCA-based probes to fluorescently label aggregated A[beta] peptides in human brain tissue from patients with Alzheimer's disease. The effects on AP binding affinity, fluorescence intensity, excitation and emission, and molecular property are presented. Furthermore, the evaluation of molecular probes as non-mechanical viscosity sensors is explored. The findings suggest that the molecular rotor motif can be applied towards designing promising new diagnostic tools for measuring viscosity in biological systems and monitoring for disease

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