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A phase i dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma
- Munster, Pamela;
- Bergsland, Emily;
- Kelley, Robin Kate;
- Bendell, JC;
- Kelley, RK;
- Shih, KC;
- Grabowsky, JA;
- Jones, S;
- Martin, T;
- Infante, JR;
- Mischel, PS;
- Matsutani, T
Published Web Location
http://europepmc.org/articles/PMC4832308?pdf=renderNo data is associated with this publication.
Abstract
© 2015 American Cancer Society.BACKGROUND The mammalian target of rapamycin (mTOR) pathway is essential for tumor development, yet mTOR inhibitors have yielded modest results. This phase 1 study investigated the mTORC1/mTORC2 inhibitor CC-223 in patients w
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