Skip to main content
eScholarship
Open Access Publications from the University of California

Role of PEX5 ubiquitination in maintaining peroxisome dynamics and homeostasis.

  • Author(s): Wang, Wei
  • Wang, Wei
  • Subramani, Suresh
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731411/
No data is associated with this publication.
Abstract

Peroxisomes are essential and dynamic organelles that allow cells to rapidly adapt and cope with changing environments and/or physiological conditions by modulation of both peroxisome biogenesis and turnover. Peroxisome biogenesis involves the assembly of peroxisome membranes and the import of peroxisomal matrix proteins. The latter depends on the receptor, PEX5, which recognizes peroxisomal matrix proteins in the cytosol directly or indirectly, and transports them to the peroxisomal lumen. In this review, we discuss the role of PEX5 ubiquitination in both peroxisome biogenesis and turnover, specifically in PEX5 receptor recycling, stability and abundance, as well as its role in pexophagy (autophagic degradation of peroxisomes).

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item