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Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis
Published Web Location
https://doi.org/10.1021/jacs.2c12779Abstract
As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
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