UC Santa Cruz
Differential regulation of germline apoptosis in response to meiotic checkpoint activation
- Author(s): Ye, AL
- Matthew Ragle, J
- Conradt, B
- Bhalla, N
- et al.
Published Web Locationhttps://doi.org/10.1534/genetics.114.170241
© 2014 by the Genetics Society of America. In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
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