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Open Access Publications from the University of California

Differential regulation of germline apoptosis in response to meiotic checkpoint activation

  • Author(s): Ye, AL
  • Matthew Ragle, J
  • Conradt, B
  • Bhalla, N
  • et al.

© 2014 by the Genetics Society of America. In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

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