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BioSciences

Lawrence Berkeley National Laboratory

Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry

Published Web Location

https://doi.org/10.1016/j.cell.2007.01.005
Abstract

The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.

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