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In vivo triglyceride composition of abdominal adipose tissue measured by 1H MRS at 3T
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332519/pdf/nihms-811942.pdfNo data is associated with this publication.
Abstract
Purpose
To investigate the regional variability of adipose tissue triglyceride composition in vivo using 1 H MRS, examining potential confounders and corrections for artifacts, to allow for adipose tissue spectrum estimation.Materials and methods
1 H magnetic resonance (MR) stimulated echo acquisition mode (STEAM) spectra were acquired in vivo at 3T from 340 adult patients (mean age 48.9 years, range 21-79 years; 172 males, 168 females; mean body mass index [BMI] 34.0, range 22-49 kg/m2 ) with known or suspected nonalcoholic fatty liver disease (NAFLD) in deep (dSCAT), surface (sSCAT) subcutaneous adipose tissue, and visceral adipose tissue (VAT). Triglyceride composition was characterized by the number of double bonds (ndb) and number of methylene-interrupted double bonds (nmidb). A subset of patients (dSCAT n = 80, sSCAT n = 55, VAT n = 194) had the acquisition repeated three times to examine the repeatability of ndb and nmidb estimation.Results
Mean ndb and nmidb showed significant (P < 0.0001) differences between depots except for dSCAT and sSCAT nmidb (dSCAT ndb 2.797, nmidb 0.745; sSCAT ndb 2.826, nmidb 0.737; VAT ndb 2.723, nmidb 0.687). All ndb and nmidb estimates were highly repeatable (VAT ndb ICC = 0.888, nmidb ICC = 0.853; sSCAT: ndb ICC = 0.974, nmidb ICC = 0.964; dSCAT: ndb ICC = 0.959, nmidb ICC = 0.948).Conclusion
Adipose tissue composition can be estimated repeatably using 1 H MRS and different fat depots have different triglyceride compositions.Level of evidence
2 J. MAGN. RESON. IMAGING 2017;45:1455-1463.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.