UC San Diego

Purpose To evaluate the relationship between the burden of chronic thromboembolic disease quantified via CT pulmonary angiography and pre-operative hemodynamics and post-operative hemodynamic improvement in CTEPH patients undergoing PTE. Methods CTEPH patients who underwent pulmonary thromboendarterectomy surgery (PTE) between December 2017 and August 2019 were retrospectively screened for having 1) preoperative CT pulmonary angiogram (CTPAs) with corresponding preoperative vascular annotations, 2) preoperative right heart catheterization, 3) bilateral level 2 surgical disease (defined from surgically resected thromboembolic specimen) and 4) recorded postoperative hemodynamics. Clot burden was quantified in preoperative CTPAs using the Qanadli score, which weights the location and severity of thromboembolic lesions into a per-patient score. Mean pulmonary artery pressure, pulmonary vascular resistance, and total pulmonary resistance were obtained from right heart catheterization preoperatively and then on the day of Swan-Ganz removal in the ICU postoperatively. Linear regression was performed between measured clot burden and hemodynamic variables. Continuous variables are presented as mean ± standard deviation. Results 15 patients (7 females, age: 36 ± 13 years, BMI: 35.0 ± 6.7, preoperative mPAP: 40 ± 13 mmHg) met all inclusion criteria. Clot burden score ranged from 11 to 30, with a mean of 19 ± 6. Level of surgical disease seen on imaging matched surgical findings in 87% and 67% of cases (right and left lungs, respectively). Figure 1 illustrates the significant linear correlations between clot burden and preoperative mPAP (R2= 0.59), PVR (R2 = 0.69) and TPR (R2= 0.58), as well as post PTE improvement in PVR (R2 = 0.48) and TPR (R2 = 0.35). Conclusion Pre-operative CT-based quantitative assessment of the pulmonary vasculature is associated with the hemodynamic severity of CTEPH and surgical improvement in PVR after PTE.