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Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.
- Bischoff, Megan;
- Shamsaei, Behrouz;
- Yang, Juechen;
- Secic, Dina;
- Vemuri, Bhargav;
- Reisz, Julie;
- DAlessandro, Angelo;
- Bartolacci, Caterina;
- Adamczak, Rafal;
- Schmidt, Lucas;
- Wang, Jiang;
- Martines, Amelia;
- Venkat, Jahnavi;
- Tcheuyap, Vanina;
- Biesiada, Jacek;
- Behrmann, Catherine;
- Vest, Katherine;
- Brugarolas, James;
- Scaglioni, Pier;
- Plas, David;
- Patra, Krushna;
- Gulati, Shuchi;
- Landero Figueroa, Julio;
- Meller, Jarek;
- Cunningham, John;
- Czyzyk-Krzeska, Maria
Published Web Location
https://doi.org/10.1158/2159-8290.CD-24-0187Abstract
The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.
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