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Open Access Publications from the University of California
Cover page of Temporal Trends and Patterns in Heart Failure with Improved Left Ventricular Ejection Fraction: A Retrospective Cohort Study

Temporal Trends and Patterns in Heart Failure with Improved Left Ventricular Ejection Fraction: A Retrospective Cohort Study

(2023)

Heart failure (HF) with reduced ejection fraction (HFrEF) remains a leading cause of morbidity and mortality. Heart failure withimproved ejection fraction (HFimpEF) has better prognosis and outcomes. However, improvement only occurs in a subpopulationof HFrEF.

Cover page of Deriving a Rule for Termination of Resuscitation in Pediatric Out-of-Hospital Cardiac Arrest

Deriving a Rule for Termination of Resuscitation in Pediatric Out-of-Hospital Cardiac Arrest

(2023)

Pediatric out-of-hospital cardiac arrest (OHCA) is an uncommon and stressful situation for providers. Despite advanced life support interventions and optimal resuscitationtechniques, pediatric OHCA carries a low survival rate of 11.3%.  Accepted criteria exist for adult patients, but not children. There is a need to develop criteria to guide termination ofresuscitation in cases when continued care would be futile.

Cover page of A Zip Code Tabulation Area-Level Analysis of Food Insecurity and Social Determinants of Coronary Heart Disease in California

A Zip Code Tabulation Area-Level Analysis of Food Insecurity and Social Determinants of Coronary Heart Disease in California

(2023)

Coronary heart disease (CHD) is the most common type of cardiovascular disease (CVD), affecting 7.2% of adults ≥ 20 years of age in the United States (U.S.). CHD prevalence is disproportionately high amongCalifornia’s (CA) racial and ethnic minority populations. Social determinants of health (SDOH) play a significant role in CHD and CVD risk factors, which have a higher prevalence among Hispanics and Blacks. Among the key SDOH that drive disparities in CHD is access to nutritious food. There are barriers to the availability of foods that support healthy eating patterns, such as living in a “food desert,” or low-income areas where nutritious food sources are limited. Other SDOH associated with CHD outcomes include socioeconomic (SES) factors, such as education andhealth insurance status.

Cover page of Do the Social Determinants of Health affect Myocardial Infarction Prognosis?

Do the Social Determinants of Health affect Myocardial Infarction Prognosis?

(2023)

Myocardial infarctions (MIs) largely contribute to the US Cardiovascular disease burden with over 800,00 MIs per year. Previous work has shown that the prognosis for sub-groups patients post MI is variable. Investigations of extrinsic factors such as the social determinants of health (SoDH), that possibly impact prognosis, are limited. The aim of this study is to determine what social factors may relate and/or contribute to MI prognosis after medical therapies.

Cover page of Assessing Racial Bias in Pulse Oximetry Using Graded Skin Tone Scale

Assessing Racial Bias in Pulse Oximetry Using Graded Skin Tone Scale

(2023)

Race and ethnicity correlate poorly with skin color. Despite a statistical significance difference in SaO2 – SpO2 across all MMSTS, it is unclear if there is a clinical significance to these findings as there is no trend between SaO2 – SpO2 and MMSTS.

Cover page of An Observational Study Comparing Intrathoracic Pressure Changes and Stroke Volume Variation with Abdominal Insufflation: SVV vs Pes

An Observational Study Comparing Intrathoracic Pressure Changes and Stroke Volume Variation with Abdominal Insufflation: SVV vs Pes

(2023)

Compare and correlate predictive agreementbetween Pes and Edwards ClearSite hemodynamic measurement changesfollowing abdominal insufflation.

Cover page of Low Voltage Areas in Left Atrium are Related to Delayed Invasive Care for Atrial Fibrillation

Low Voltage Areas in Left Atrium are Related to Delayed Invasive Care for Atrial Fibrillation

(2023)

Areas of low voltage electrograms (<0.5 mV) (LVA) are known to correlate with areas of atrial fibrosis and are related to clinical outcomes after ablation. We hypothesized that delay in seeking invasive treatment is linked to larger LVA.

Cover page of Intensive blood pressure lowering in individuals with low diastolic blood pressure and elevated troponin levels in SPRINT

Intensive blood pressure lowering in individuals with low diastolic blood pressure and elevated troponin levels in SPRINT

(2023)

Hypertension (HTN) affects ~1.4 billion people worldwide and is a leading cause of cardiovascular disease (CVD) and earlydeath. Recent guidelines recommend lower blood pressure (BP) targets, but the optimal BP target for individuals with low diastolic BP (DBP) remains controversial because of the Jcurve phenomenon:  Low DBP is associated with increased CVD risk and death, thought to be due to reduced coronary perfusion indiastole. High sensitivity cardiac troponin T (hs-cTnT), a biomarker of subclinical myocardial injury, may be able to identify individualswith low DBP at-risk of harm from additional BP lowering. However, there are no data from randomized trials on whether lower BP targets have similar CVD and mortality benefits inindividuals with low DBP and elevated hs-cTnT.

Cover page of Onset of Atrial Fibrillation Recurrences in Patients Post Ablation

Onset of Atrial Fibrillation Recurrences in Patients Post Ablation

(2023)

There are still gaps in our knowledge regardingthe pathogenesis, prevention as well asapproaches to improve success in themanagement of atrial fibrillation (AF). Catheter ablation remains one of the preferredtreatment options for paroxysmal, persistent, and long- standing AF.

The goal of this prospective cohort study was to determine which type of AF is more likely to have recurrences post catheter ablation and when the recurrence is most likely to occur.

Cover page of Volumetric intracardiac echocardiography (vICE) is feasible for procedural guidance of transcatheter mitral edge-to-edge repair (mTEER)

Volumetric intracardiac echocardiography (vICE) is feasible for procedural guidance of transcatheter mitral edge-to-edge repair (mTEER)

(2023)

Transcatheter mitral edge-to edge repair(mTEER) is a minimally invasive, catheter-based therapy used to treat mitralregurgitation. The gold standard for intraprocedural guidance of mTEER is transesophageal echocardiography (TEE).4-dimensional volumetric intracardiacechocardiography (vICE) is an alternativeimaging modality that provides volumetricimages with multiplanar reconstruction forguidance during structural heart procedures.