Long-term management strategies to preserve graft function in post-renal transplant patients have largely remained stagnant. Whole-food plant-based dietary counseling has beenshown to reduce the incidence of comorbidities(diabetes, dyslipidemia, and hypertension) that post-transplant patients are at increased risk for developing. It is not yet standard-of-care to offer post-transplant patients long-term dietary counseling. Whole-food plant-based dietary counseling is a cost-effective and safe intervention that can be widely distributed.This examines if three months of whole-food plant-based dietary counseling in post-renal transplant patients can reduce the incidence of comorbidities thus improving graft & patient outcome.
Chronic kidney disease (CKD) is associated with skeletal muscle dysfunction leading to decreased physical functioning. Reduced kidney function leads to impaired muscle mitochondrial oxidative capacity underlying poor physical performance. The link between muscle mitochondrial oxidative capacity and patient-reported vs. objective measures of physical activity (PA) remains unclear. Objective: Determine the association between in-vivo leg muscle mitochondrial capacity and self-reported PA and objective PA.
An accurate determination of Glomerular Filtration Rate (GFR) is essential in the evaluation of living kidney donors. The gold standard measurement of GFR is urinary clearance of inulin, which is a cumbersome and difficult testing process. Iohexol is a non-ionic contrast agent with low extrarenal excretion, tubular secretion or reabsorption, and protein binding affinity, and is therefore a good agent for measurement of GFR (mGFR).
Iohexol has also been found to be virtually non-toxic, with low cost and can yield mGFR with one timed blood draw.
Chronic kidney disease (CKD) is associated with skeletal muscle dysfunction leading to decreased physical functioning. Reduced kidney function leads to impaired muscle mitochondrial oxidative capacity underlying poor physical performance. The link between muscle mitochondrial oxidative capacity and patient-reported and objective measures of physical activity (PA) remains unclear.
Tuberous Sclerosis (TS) is a genetic disorder that affects multiple organ systems and is associated with growth of non-malignant hamartomas throughout the body. The disease is highly associated with seizures, cognitive impairments, and behavioral or social deficits such as ASD or ADHD.
There have been various studies examining the association between TS and intellectual and behavioral outcomes for young patients using event related potentials (ERPs) obtained on EEG. This includes the Mismatch Negativity (MMN) ERP. The measurement of these potentials is a reliable, non-invasive method to compare brain activity patterns across subjects. Following from previous study data, we want to explore specific, altered patterns of electrical activity in TS patients with ASD that are distinct from those found in TS patients without ASD.
Brain injury is the most serious and most extensively studied complication of pediatric DKA. Lifethreatening brain injury occurs in 0.5-1% of pediatric DKA episodes (1), however, more subtle injury occurs frequently, causing cognitive deficits that are detectable after even a single DKA episode. Similarly, renal failure is an infrequent consequence of DKA, however, recent data demonstrate that less severe acute kidney injury (AKI) occurs commonly (2). These data suggest that organ injuries during DKA may not occur as isolated events but instead reflect a form of multiple organ dysfunction syndrome. Importantly, patterns of organ involvement in DKA largely mirror patterns of chronic organ dysfunction that are characteristic of T1D in adulthood. Data from other brain and kidney diseases suggests that inflammatory processes triggered during acute injury may persist chronically and contribute to long-term organ dysfunction. Understanding the processes leading to organ dysfunction during DKA in childhood therefore may have far-reaching implications, extending beyond the acute time frame associated with DKA.
