Open Access Policy Deposits

Parent: Department of Biological Chemistry, UCLA, David Geffen School of Medicine

eScholarship stats: History by Item for March through June, 2025

Item	Title	Total requests	2025-06	2025-05	2025-04	2025-03
3bm6r902	Cell Biology of the Mitochondrion	172	46	29	44	53
4h4495x5	Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase	159	121	14	15	9
0nj3p8sn	Cell Biology of Canonical Wnt Signaling	153	56	33	22	42
1q76t50g	Lactate dehydrogenase activity drives hair follicle stem cell activation	148	120	14	10	4
9q72d0dk	CRISPR-based targeting of DNA methylation in Arabidopsis thaliana by a bacterial CG-specific DNA methyltransferase	142	63	30	24	25
8cs8z9p3	Improving the solubility of pseudo-hydrophobic chemicals through co-crystal formulation.	134	22	27	42	43
68v1446k	Photoaffinity labelling strategies for mapping the small molecule–protein interactome	130	71	40	13	6
9185g8gj	Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis.	130	78	23	15	14
0fh0h194	Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos	129	47	28	21	33
4q99m9rw	Accurate design of co-assembling multi-component protein nanomaterials	128	71	57
0w64157x	Internal Fragments Enhance Middle-Down Mass Spectrometry Structural Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates.	123	26	24	16	57
59b2218p	Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces	114	54	60
9nh2d4t3	The cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair	114	43	31	15	25
06k5w7g0	Structure of the lens MP20 mediated adhesive junction.	112	43	34	35
77t5d3q4	ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.	108	31	67	3	7
4ph8w0v1	Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing	107	50	21	22	14
3g79735q	MicroED Structures of Fluticasone Furoate and Fluticasone Propionate Provide New Insights into Their Function.	106	41	31	34
5vg8s806	Systematic discovery of conservation states for single-nucleotide annotation of the human genome.	104	25	20	16	43
2mc7j5vs	Tandem metabolic reaction-based sensors unlock in vivo metabolomics.	103	37	31	35
56j017g9	Single nucleus multi-omics identifies human cortical cell regulatory genome diversity	101	37	31	17	16
6274g8m7	Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health	101	36	50	8	7
05p11699	Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants.	100	30	10	12	48
8xm482tk	Engineering an allosteric transcription factor to respond to new ligands.	100	73	16	5	6
5272f4bc	A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience	99	62	18	8	11
70b2315v	DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)	99	43	23	14	19
6qp7s3cc	Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor	97	34	47	9	7
064987qh	Recovering high-resolution information using energy filtering in MicroED.	95	51	44
6vq1b3ps	Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex	95	36	22	12	25
8f18t8wn	Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED.	95	69	11	7	8
9bd8z0hh	Substrate twinning activates the signal recognition particle and its receptor	95	27	28	22	18
6cn1q64t	Defects in the Medial Entorhinal Cortex and Dentate Gyrus in the Mouse Model of Sanfilippo Syndrome Type B	94	27	52	9	6
6nv0q883	De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals	93	35	21	16	21
8mx9d13m	CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization	93	50	19	13	11
08d3p8vk	Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth	92	39	23	15	15
54g7c1bp	Cortical regulation of helping behaviour towards others in pain.	92	30	21	15	26
5pr5k9vr	Energy filtering enables macromolecular MicroED data at sub-atomic resolution.	92	38	29	25
1z72474s	BMP gradients: A paradigm for morphogen-mediated developmental patterning	91	31	25	14	21
38v8j6fz	A high-resolution map of human evolutionary constraint using 29 mammals	91	49	13	17	12
78z3640x	Genome-wide analysis of dorsal and ventral transcriptomes of the Xenopus laevis gastrula	91	36	16	17	22
5v00z3sf	Atlas of fetal metabolism during mid-to-late gestation and diabetic pregnancy.	90	49	22	7	12
62j4r8dn	Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression	90	34	56
7s9850mt	N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma	90	50	23	13	4
82q3d98q	Vision-dependent specification of cell types and function in the developing cortex	90	39	20	20	11
8619753x	In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse.	90	33	13	17	27
2b27t47j	Structural Characterization of a Thrombin-Aptamer Complex by High Resolution Native Top-Down Mass Spectrometry	89	79	4	1	5
3t8708z1	Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes	89	33	13	17	26
9nf8q0sh	Histone H3 cysteine 110 enhances iron metabolism and modulates replicative life span in Saccharomyces cerevisiae.	89	34	29	26
9nj3h75b	Top-down proteomics.	89	45	26	10	8
07r1j11r	Insight into the autoproteolysis mechanism of the RsgI9 anti-σ factor from Clostridium thermocellum.	88	56	14	15	3
35s312ff	An activation-based high throughput screen identifies caspase-10 inhibitors	88	40	24	24

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