Department of Cellular & Molecular Medicine - Open Access Policy Deposits

eScholarship stats: Breakdown by Item for April through July, 2024

Item	Title	Total requests	Download	View-only	%Dnld
9044v022	Brain organoids, consciousness, ethics and moral status	185	62	123	33.5%
6tk62335	An essential and highly selective protein import pathway encoded by nucleus-forming phage	146	4	142	2.7%
70c3m48j	Spindle assembly checkpoint activation and silencing at kinetochores.	104	35	69	33.7%
0tt0x846	Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management	103	5	98	4.9%
9s9286nj	Identification of H3K4me1-associated proteins at mammalian enhancers	96	10	86	10.4%
8j35h8jn	Architecture and self‐assembly of the SARS‐CoV‐2 nucleocapsid protein	88	15	73	17.0%
85j9m77h	Control of bacterial immune signaling by a WYL domain transcription factor	84	19	65	22.6%
232927v1	SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2	78	19	59	24.4%
50w2z43f	Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer	73	9	64	12.3%
8s13b2f8	Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development	71	6	65	8.5%
219597nn	Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis	70	21	49	30.0%
8jj6580k	Sialoglycan-binding patterns of bacterial AB<sub>5</sub> toxin B subunits correlate with host range and toxicity, indicating evolution independent of A subunits.	70	1	69	1.4%
1m706149	Reversing a model of Parkinson’s disease with in situ converted nigral neurons	69	17	52	24.6%
3vq7746f	GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery	65	10	55	15.4%
4rs831wx	Excitatory motor neurons are local oscillators for backward locomotion	65	9	56	13.8%
2231q4mb	Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration	64	10	54	15.6%
4vt1n111	A phage nucleus-associated RNA-binding protein is required for jumbo phage infection	60	27	33	45.0%
0h227304	The cytoplasmic dynein transport machinery and its many cargoes	59	50	9	84.7%
3710176w	Gap junctions: historical discoveries and new findings in the Caenorhabditis elegans nervous system	59	11	48	18.6%
44q19509	C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2α phosphorylation	59	9	50	15.3%
6z9096mf	An in vivo neuroimmune organoid model to study human microglia phenotypes.	59	9	50	15.3%
404994bx	Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss	58	6	52	10.3%
0r65r9b9	Interactome analysis illustrates diverse gene regulatory processes associated with LIN28A in human iPS cell-derived neural progenitor cells	57	11	46	19.3%
4f33s5hg	MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C)	57	12	45	21.1%
0xm8q84f	Circular ecDNA promotes accessible chromatin and high oncogene expression	51	14	37	27.5%
7b11m3h2	Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals	51	11	40	21.6%
2dt4875d	Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin	48	19	29	39.6%
5kd0v4kq	Large-scale tethered function assays identify factors that regulate mRNA stability and translation	47	23	24	48.9%
4cf9h3d3	The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients	46	27	19	58.7%
9ns984bk	Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes	41	16	25	39.0%
4z473969	SRSF2 Is Essential For Hematopoiesis and Its Mutations Dysregulate Alternative RNA Splicing In MDS	40	7	33	17.5%
4bc6c9wg	Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro	39	22	17	56.4%
0503r9x1	Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19	38	14	24	36.8%
27h418pp	Chromosomal instability drives metastasis through a cytosolic DNA response	38	19	19	50.0%
5qz4h5f8	Nuclei isolation of multiple brain cell types for omics interrogation	38	9	29	23.7%
3pv76061	E-cigarettes compromise the gut barrier and trigger inflammation	36	26	10	72.2%
9t0682cv	Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis	36	3	33	8.3%
0dh6t524	The conserved XPF:ERCC1-like Zip2:Spo16 complex controls meiotic crossover formation through structure-specific DNA binding	35	28	7	80.0%
4q83z0wz	Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms	35	7	28	20.0%
1zt4w4dz	The Three-Dimensional Organization of Mammalian Genomes	34	9	25	26.5%
3w54c6ks	Single-Cell Imaging of Metastatic Potential of Cancer Cells	34	11	23	32.4%
77f9r1t7	Drug repurposing screens identify chemical entities for the development of COVID-19 interventions	34	19	15	55.9%
9ch9c08j	Misfolded SOD1 is not a primary component of sporadic ALS	34	13	21	38.2%
1cp2v8ct	An ultra high-throughput method for single-cell joint analysis of open chromatin and transcriptome	33	15	18	45.5%
48f8272d	Brain cell type–specific enhancer–promoter interactome maps and disease-risk association	33	15	18	45.5%
4rn7d07h	Joint profiling of histone modifications and transcriptome in single cells from mouse brain	33	17	16	51.5%
6n67p3m0	Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease	33	19	14	57.6%
8sh2k9v8	Site-Specific and Enzymatic Cross-Linking of sgRNA Enables Wavelength-Selectable Photoactivated Control of CRISPR Gene Editing	33	17	16	51.5%
0pw1p3s3	TRIM37 controls cancer-specific vulnerability to PLK4 inhibition	32	16	16	50.0%
7bp0w94j	Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson’s disease	32	11	21	34.4%

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Disclaimer: due to the evolving nature of the web traffic we receive and the methods we use to collate it, the data presented here should be considered approximate and subject to revision.