- Rolfes, Mary;
- Harroud, Adil;
- Zorn, Kelsey C;
- Tubati, Asritha;
- Omura, Charles;
- Kurtz, Kenneth;
- Matloubian, Mehrdad;
- Berger, Amy;
- Chiu, Charles Y;
- Wilson, Michael R;
- Ramachandran, Prashanth S
Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta.