Biological Systems & Engineering

eScholarship stats: History by Item for March through June, 2026

Item	Title	Total requests	2026-06	2026-05	2026-04	2026-03
7s7342wx	Evaluation of bacterial hosts for conversion of lignin-derived p-coumaric acid to 4-vinylphenol	814	167	172	173	302
6xs6568m	Slot Blot Assay for Detection of R Loops	805	169	235	242	159
0f40r591	Recent Advances in the Use of Ionic Liquids and Deep Eutectic Solvents for Lignocellulosic Biorefineries and Biobased Chemical and Material Production	617	87	152	199	179
5n75t404	Pre-metastatic niches: organ-specific homes for metastases	617	174	155	144	144
9d4221mc	De novo DNA synthesis using polymerase-nucleotide conjugates	606	145	181	129	151
9g36j1zs	Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies	601	84	212	189	116
60s4z9wm	Tumour exosome integrins determine organotropic metastasis	600	160	190	166	84
2n42n48w	The Impact of Electric Fields on Processes at Electrode Interfaces	598	186	189	131	92
3799153s	33 Unresolved Questions in Nanoscience and Nanotechnology	573	109	88	211	165
9pm0x5mh	Machine learning for metabolic engineering: A review	570	177	156	120	117
9bk272nb	Evolution-guided tolerance engineering of Pseudomonas putida KT2440 for production of the aviation fuel precursor isoprenol	551	153	156	133	109
5ns091ht	Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Resolving the hot and ionized Universe through the Sunyaev-Zeldovich effect	478	114	125	109	130
66k3m8h5	Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents	475	137	167	101	70
2hg7004n	Systematic assessment of long-read RNA-seq methods for transcript identification and quantification	471	95	167	113	96
3qf33012	Binary vector copy number engineering improves Agrobacterium-mediated transformation	448	134	134	113	67
4369p87c	Methane to bioproducts: unraveling the potential of methanotrophs for biomanufacturing	442	105	123	91	123
75g874b4	Biosystem design of Corynebacterium glutamicum for bioproduction	439	119	128	109	83
2mq4z3j6	Complete biosynthesis of QS-21 in engineered yeast	424	129	131	98	66
43x013sh	Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus	422	28	336	29	29
2zw971kg	Metabolic engineering strategies for sesquiterpene production in microorganism	413	98	128	105	82
57g863q6	A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses	413	26	340	21	26
6r99w1b4	Complete biosynthesis of cannabinoids and their unnatural analogues in yeast	404	87	124	110	83
77f5s184	The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	398	106	92	68	132
87h7j1t3	Verazine biosynthesis from simple sugars in engineered Saccharomyces cerevisiae	388	88	109	106	85
8dh7k2k4	The complex polyploid genome architecture of sugarcane	386	91	143	86	66
2ww6f9d2	Complete genomic and epigenetic maps of human centromeres	380	100	98	98	84
6gk6f7js	Genetic variations and their interaction with thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice	376	78	135	163
3qw331qh	Chemoselective Methylation of Phenolic Hydroxyl Group Prevents Quinone Methide Formation and Repolymerization During Lignin Depolymerization	363	49	77	122	115
6bz273tk	Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	360	73	108	114	65
1j47k8qk	Production Cost and Carbon Footprint of Biomass-Derived Dimethylcyclooctane as a High-Performance Jet Fuel Blendstock	358	29	170	80	79
1ct062cx	Nitrogen Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing	348	92	91	98	67
7294g81k	Heterochromatin: Guardian of the Genome	342	79	86	78	99
06n5h0nh	Hydrogen storage and geo-methanation in a depleted underground hydrocarbon reservoir	341	80	134	74	53
2jx454ms	Neurospora intermedia from a traditional fermented food enables waste-to-food conversion	339	89	84	83	83
1gq1w12k	Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype	336	135	89	66	46
25s902m0	Microbial production of advanced biofuels	336	71	92	104	69
62d7n4g9	Designing a broad-spectrum integrative approach for cancer prevention and treatment	335	36	102	110	87
3q12x1gh	Perspectives for self-driving labs in synthetic biology	334	82	123	70	59
29n9q5d3	Biosensor-driven strain engineering reveals key cellular processes for maximizing isoprenol production in Pseudomonas putida	331	97	102	71	61
2nx9f1fj	Thirdhand Smoke: New Evidence, Challenges, and Future Directions	327	103	93	87	44
13g9r2dw	Recent developments of oleaginous yeasts toward sustainable biomanufacturing	324	81	103	85	55
4j8893w1	Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging	321	105	48	61	107
71q1b4jn	A map of the rubisco biochemical landscape	321	88	96	69	68
38g6r8jw	Systematic engineering for production of anti-aging sunscreen compound in Pseudomonas putida	319	80	89	99	51
0127v3td	Spatially Resolved Quantum Sensing with High-Density Bubble-Printed Nanodiamonds	316	87	108	74	47
7bf9b2j1	Mapping protein–DNA interactions with DiMeLo-seq	313	97	88	82	46
61r4c30v	Deconstruction of Woody Biomass via Protic and Aprotic Ionic Liquid Pretreatment for Ethanol Production	310	107	70	99	34
7w28865m	Predictive CRISPR-mediated gene downregulation for enhanced production of sustainable aviation fuel precursor in Pseudomonas putida	299	77	88	65	69
6q23g280	A proteomic atlas of senescence-associated secretomes for aging biomarker development	296	68	74	79	75
000938pk	Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD‐L1)‐mediated immunosuppression	295	89	84	58	64

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