Biological Systems & Engineering

eScholarship stats: History by Item for May through August, 2026

Item	Title	Total requests	2026-08	2026-07	2026-06	2026-05
4j8893w1	Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging	1,078	820	105	105	48
60s4z9wm	Tumour exosome integrins determine organotropic metastasis	798	331	117	160	190
6xs6568m	Slot Blot Assay for Detection of R Loops	753	180	169	169	235
5n75t404	Pre-metastatic niches: organ-specific homes for metastases	706	202	175	174	155
9d4221mc	De novo DNA synthesis using polymerase-nucleotide conjugates	686	139	221	145	181
2n42n48w	The Impact of Electric Fields on Processes at Electrode Interfaces	678	151	152	186	189
9pm0x5mh	Machine learning for metabolic engineering: A review	648	144	171	177	156
2mq4z3j6	Complete biosynthesis of QS-21 in engineered yeast	589	192	137	129	131
7s7342wx	Evaluation of bacterial hosts for conversion of lignin-derived p-coumaric acid to 4-vinylphenol	573	109	125	167	172
3799153s	33 Unresolved Questions in Nanoscience and Nanotechnology	481	258	26	109	88
1gq1w12k	Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype	471	176	71	135	89
2zw971kg	Metabolic engineering strategies for sesquiterpene production in microorganism	469	168	75	98	128
9bk272nb	Evolution-guided tolerance engineering of Pseudomonas putida KT2440 for production of the aviation fuel precursor isoprenol	460	62	89	153	156
77f5s184	The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice	457	220	39	106	92
3qf33012	Binary vector copy number engineering improves Agrobacterium-mediated transformation	453	97	88	134	134
5ns091ht	Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Resolving the hot and ionized Universe through the Sunyaev-Zeldovich effect	446	87	120	114	125
2hg7004n	Systematic assessment of long-read RNA-seq methods for transcript identification and quantification	437	66	109	95	167
75g874b4	Biosystem design of Corynebacterium glutamicum for bioproduction	426	102	77	119	128
9g36j1zs	Maximizing Heterologous Expression of Engineered Type I Polyketide Synthases: Investigating Codon Optimization Strategies	424	85	43	84	212
57g863q6	A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses	407	16	25	26	340
6r99w1b4	Complete biosynthesis of cannabinoids and their unnatural analogues in yeast	404	110	83	87	124
66k3m8h5	Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents	401	41	56	137	167
2ww6f9d2	Complete genomic and epigenetic maps of human centromeres	389	113	78	100	98
0f40r591	Recent Advances in the Use of Ionic Liquids and Deep Eutectic Solvents for Lignocellulosic Biorefineries and Biobased Chemical and Material Production	382	80	63	87	152
43x013sh	Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus	379	9	6	28	336
3939k3wv	Land Resources for Wind Energy Development Requires Regionalized Characterizations	377	151	85	55	86
7294g81k	Heterochromatin: Guardian of the Genome	369	103	101	79	86
6940v666	Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients	360	84	108	104	64
87h7j1t3	Verazine biosynthesis from simple sugars in engineered Saccharomyces cerevisiae	352	64	91	88	109
8dh7k2k4	The complex polyploid genome architecture of sugarcane	349	56	59	91	143
6bz273tk	Galactic cosmic ray simulation at the NASA space radiation laboratory – Progress, challenges and recommendations on mixed-field effects	345	82	82	73	108
2zr0520r	Advanced pathways for hydrogen production: a collective view from a technical experts meeting	343	123	24	65	131
71q1b4jn	A map of the rubisco biochemical landscape	343	84	75	88	96
06n5h0nh	Hydrogen storage and geo-methanation in a depleted underground hydrocarbon reservoir	338	77	47	80	134
2nx9f1fj	Thirdhand Smoke: New Evidence, Challenges, and Future Directions	338	70	72	103	93
25s902m0	Microbial production of advanced biofuels	334	81	90	71	92
46b3v6xc	Geroscience: Linking Aging to Chronic Disease	328	130	78	64	56
4369p87c	Methane to bioproducts: unraveling the potential of methanotrophs for biomanufacturing	326	47	51	105	123
6gk6f7js	Genetic variations and their interaction with thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice	326	58	55	78	135
1ct062cx	Nitrogen Metabolism in Pseudomonas putida: Functional Analysis Using Random Barcode Transposon Sequencing	323	67	73	92	91
2jx454ms	Neurospora intermedia from a traditional fermented food enables waste-to-food conversion	322	74	75	89	84
3q12x1gh	Perspectives for self-driving labs in synthetic biology	319	75	39	82	123
8xg3g0x6	IMG/PR: a database of plasmids from genomes and metagenomes with rich annotations and metadata	312	53	70	87	102
6dr6v4vg	Adsorptive recovery of volatile fatty acids from wastewater fermentation broth	309	76	40	72	121
42k112z2	A genomic catalog of Earth’s microbiomes	308	81	53	85	89
1dm2j12r	The tier system: a host development framework for bioengineering	306	114	79	43	70
13g5b11t	A modERN resource: identification of Drosophila transcription factor candidate target genes using RNAi	304	41	103	94	66
2pd1334b	From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence	299	148	33	54	64
61r4c30v	Deconstruction of Woody Biomass via Protic and Aprotic Ionic Liquid Pretreatment for Ethanol Production	298	55	66	107	70
3f52f72c	Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo	293	36	61	86	110

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