Fertility control in wildlife is emerging as a potential management tool. Published research on feral horses, deer, rodents, and rabbits suggest an effective agent producing reversible infertility in these species could be developed. Furthermore, anecdotal reports suggest that infertility can be induced in a greater array of species. In this paper, the authors review methods of fertility control being studied for application in wildlife and focus on their studies designed to evaluate the effectiveness of fertility control agents in coyotes (Canis latrans). Immunocontraception using porcine zona pellucida (PZP) is currently the most promising method of fertility control in coyotes the authors have studied. This is consistent with results from other species. However, the vital question of whether any fertility control agent can reduce livestock losses due to coyote predation will require more research.