- Nakanishi, Rine;
- Post, Wendy S;
- Osawa, Kazuhiro;
- Jayawardena, Eranthi;
- Kim, Michael;
- Sheidaee, Nasim;
- Nezarat, Negin;
- Rahmani, Sina;
- Kim, Nicholas;
- Hathiramani, Nicolai;
- Susarla, Shriraj;
- Palella, Frank;
- Witt, Mallory;
- Blaha, Michael J;
- Brown, Todd T;
- Kingsley, Lawrence;
- Haberlen, Sabina A;
- Dailing, Christopher;
- Budoff, Matthew J
Background and aim
The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA).Patients and methods
HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline. We measured coronary plaque volume and characteristics (calcified and noncalcified plaque including fibrous, fibrous-fatty, and low attenuation) and vulnerable plaque among HIV-infected and uninfected men using semiautomated plaque software to investigate the progression of coronary atherosclerosis over time.Conclusion
We describe a novel, large prospective multicenter study investigating incidence, transition of characteristics, and progression in coronary atherosclerosis quantitatively assessed by serial coronary CTAs among HIV-infected and uninfected men.