Cardiotoxicity is one of the major reasons for withdrawal of drugs from the market. Hence, assessing the cardiotoxicity of drug candidates with high efficacy and accuracy during the drug development process is essential to reduce the withdrawal risk of new drugs. Excitation-contraction coupling in cardiomyocytes orchestrates the cardiac function, but the inability to record electrical and mechanical signals simultaneously has hindered the acquisition of synchronous and correlative information between the electrical and mechanical properties of cardiomyocytes. Herein, a high-throughput, easy to use, minimally invasive, accurate, and combined measurement platform for iPSC-CM action potential and contraction force is demonstrated using a Nano-electrode array, and Fluorescent nanospheres that help construct contraction forces using Traction Force Microscopy technique. This platform represents a multimodal analysis technique that can easily reach sub-cellular resolution with simultaneous use of nano-electrode array and nanospheres. First, the platform was developed and characterized without the use of cells, that included optimization of PDMS thickness, characterization of its stiffness, and optimization of nanosphere distribution density on the PDMS substrate. After optimization of measurement acquisition, separate action potential and contraction force were obtained from iPSC derived cardiomyocytes. And, the dynamic response of cardiomyocytes to caffeine was recorded and analyzed. Obtained results indicate that the platform has tremendous potential in simultaneous recording and application in patient specific cardiotoxicity screening.