What barriers do Native American and Alaskan Native students face in higher education? How are these barriers to student success being addressed theoretically and practically? To engage these questions, this special issue of the American Indian Culture and Research Journal seeks to open this dialogue and create a compilation that professors and service providers may use to enhance American Indian studies and other academic curricula. Contributors to this special issue explore a broad range of educational, cultural competence, mental health, advocacy, and efficacy concerns.